Pulmonary histoplasmosis; report of a case long considered tuberculous improved by acti-dione.

Histoplasmosis in endemic areas such as the Mississippi Valley is now considered to be the cause of many instances of pulmonary calcification formerly thought to be tubercul~us.l-~ We wish to report a case who had a pulmonary infection in 1918-19 which from 1925 to 1949 was considered to be tuberculous although tubercle bacilli were never demonstrated. Skin test and complement fixation were positive for histoplasmosis. Histoplasma capsulatum was cultured from sputum and lung tissue and was demonstrated in lung tissue removed by lobectomy. He improved clinically and the sputum no longer showed histoplasma after intensive treatment with Acti-dione.